Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. The purpose of this study was to investigate IE PWID and compare it with non-PWID patients. Two prospective cohort studies (ICE-PCS ICE-Plus databases, encompassing 8,112 episodes from 2000 2006 2008 2012, 64 34 sites 28 18 countries, respectively). Outcomes were compared between patients IE. Logistic regression analyses performed risk factors for 6-month mortality relapses amongst PWID. A total 7,616 (591 7,025 non-PWID) included. significantly younger (median 37.0 years [interquartile range: 29.5 44.2 years] vs. 63.3 49.3 74.0 years]; p < 0.001), male (72.5% 67.4%; = 0.007), presented lower rates comorbidities except human immunodeficiency virus, liver disease, higher prior Amongst cases PWID, 313 (53%) involved left-side valves 204 (34.5%) purely left-sided a larger proportion native (90.2% 64.4%; whereas prosthetic-IE cardiovascular implantable electronic device-IE more frequent (9.3% 27.0% 0.5% 8.6%; both 0.001). Staphylococcus aureus caused 65.9% 26.8% non-PWID, respectively (p systemic emboli (51.1% 22.5%; 0.001) persistent bacteremia (14.7% 9.3%; Cardiac surgery less frequently (39.5% 47.8%; in-hospital (10.8% 18.2% 14.4% 22.2%; (9.5% 2.8%; Prior IE, polymicrobial etiology, intracardiac complications, stroke mortality, cardiac associated the population. notable involve valves, prosthetic or are by microorganisms other than S. aureus.